Mkrtchyan, SatenikShalimov, Oleksandr O.Garcia, Michael G.Zapletal, JiříIaroshenko, Viktor O.2025-07-042025-07-0420242041-65202041-6539https://doi.org/10.1039/d4sc00904ehttps://repo.umb.sk/handle/123456789/698In: Chemical Science. Cambridge : Royal Society of Chemistry, 2024. ISSN 2041-6520. Vol. 15, no. 24 (2024), pp. 9155-9163.A new method has been introduced that is able to tackle the complexities of N–C(O) activation in amide moieties through utilization of pyrylium tetrafluoroborate in a mechanochemical setting, where amide bonds undergo activation and subsequent conversion to biaryl ketones. Due to the employment of a mechanochemical setting, the reaction conforms to green chemistry principles, offering an environmentally friendly approach to traditional amide derivatization techniques that rely on transition metals to achieve further functionalization.enCC BY Creative Commons Attribution 4.0. Internationalinfo:eu-repo/semantics/openAccessmechanochémiamechanochemistryketónyorganická chémiaorganic chemistryfarmaceutický priemyselpharmaceutical industryArticle