Mkrtchyan, SatenikPurohit, VishalZapletal, JiříShalimov, Oleksandr O.Iaroshenko, Viktor O.2025-06-182025-06-1820242168-0485https://doi.org/10.1021/acssuschemeng.3c04372https://repo.umb.sk/handle/123456789/640In: ACS Sustainable Chemistry & Engineering. Washington : The American Chemical Society, 2024. ISSN 2168-0485. Vol. 12, no. 1 (2024), pp. 1-9.Among a wide array of synthetic amides, N-aryl/alkyl amides are an important class of structural motifs having significant importance in pharmaceutical and agrochemical industries. In this regard, a rapid, low-cost, and environmentally friendly synthesis of N-aryl/alkyl amides still remains in a high demand. Herein, we report a convenient route for the mechanochemical synthesis of N-aryl/alkyl amides via FeCl3-catalyzed reductive amidation of nitro compounds, as well as acylation of aliphatic/aromatic amines with carboxylic acids using nanocellulose as the reaction media/stoichiometric reducing agent. The protocol was found to be simple, efficient, and environmentally benign to obtain a diverse array of the respective amides with good to excellent yields. Furthermore, the use of nitro compounds, amines, and carboxylic acids as cheap and readily available starting materials, FeCl3 as a nontoxic catalyst, and nanocellulose as the biodegradable reaction media as well as the stoichiometric reducing agent makes this protocol in the category of a green chemical transformation.enCC BY Creative Commons Attribution 4.0. Internationalinfo:eu-repo/semantics/openAccessmechanochémiamechanochemistrynitrozlúčeninynitro compoundskatalýzaArticle