Mechanochemical trifluoromethoxylation of aryltrimethylammonium triflates, aryldiazonium tetrafluoroborates, and aryl pinacolboranes
Načítavam...
Súbory
Dátum
2024
Názov časopisu
ISSN časopisu
Názov zväzku
Vydavateľ
Cell Press : Cambridge
ISBN
ISSN
2666-3864
Abstrakt
Aryl trifluoromethyl ethers (ArOCF3) are important structural motifs in pharmaceuticals, agrochemicals, and functional materials. However, the methods reported for the efficient synthesis of these scaffolds are extremely underdeveloped and limited. Here, we report a highly efficient mechanochemical approach for the selective transformation of aryltrimethylammonium triflates, aryldiazonium tetrafluoroborates, and aryl pinacolboranes to aryl trifluoromethyl ethers via in situ-generated OCF3 source using triphosgene and Co(II) fluoride (CoF2). The proposed synthetic protocol also shows potential for the selective transformation of other groups such as arylsulfonium and diaryliodonium functionalities. The present trifluoromethoxylation strategy exhibited a broad functional group tolerance and found to be superior over other existing protocols in terms of substrate scope, yields, operational simplicity, and reaction times.
Popis
In: Cell reports physical science. Cambridge : Cell Press, 2024. ISSN 2666-3864. Vol. 5, no. 8 (2024), pp. 1-15.
Kľúčové slová
mechanochémia, mechanochemistry, farmaceutický priemysel, pharmaceutical industry, agrochemikálie
Výstup z projektu
APVV-21-0362 Perfluóralkylácia - stratégia diverzifikácie komplexných organických molekúl v neskorej fáze syntézy
Citácia
Práva a licenčné podmienky
CC BY-NC-ND Creative Commons Attribution-NonCommercial-NoDerivatives 4.0. International
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess