Fakulta prírodných vied UMB

Trvalé URI pre túto komunitu

hdl:123456789/22

Prehliadať

Prehliadanie Fakulta prírodných vied UMB podľa Autor "Albertyová, Dáša"

Teraz sa zobrazuje 1 - 1 z 1
  • Obrázok miniatúry
    Položka
    Porovnanie vplyvu troch metód na výpočet LDL cholesterolu na kategorizáciu rizika kardiovaskulárnych ochorení v troch odlišných populáciách pacientov
    (Slovenská kardiologická spoločnosť : Bratislava, 2024) Gaško, Rudolf; Alberty, Roman; Studenčan, Martin; Albertyová, Dáša
    Background: Limitations of the Friedewald equation for low-density lipoprotein cholesterol (F-LDLC) calculation, which is used by ≈ 33% of laboratories in Slovakia and 66% of laboratories in Europe, led to the Martin-Hopkins (M-LDLC), extended Martin-Hopkins (extM-LDLC) and Sampson/National Institutes of Health (S-LDLC) equations. We studied these newer calculations of LDLC for correlation and discordance for stratification into the 2019 ESC/EAS Guidelines’ cardiovascular disease (CVD) risk categories. Methods: We performed analyses on lipid profiles from 3 populations: 873 healthy children from the cross-sectional Slovak Lipid Community Study (population SLCS), records of a 1949 patients of a hospital biochemistry laboratory from from a specialized cardio centre (population VÚSCH), and records of 9113 patients of a hospital biochemistry laboratory from a large general hospital (population FN FDR). Patients were categorized as concordant if LDL-C was up to ≈ 3.4% or 8.9% of patients, respectively, to a higher CVD risk category. The difference between F-LDLC and extM-LDLC or S-LDLC is greater with higher TG, and with lower LDLC. Reliance on the Friedewald equation may result in the underestimation and undertreatment of LDL-C in those at increased risk. We recommend, in line with some national/international guidelines, that clinical laboratories switch to counting and reporting results to extM-LDLC. Fig. 4, Tab. 5, Ref. 42,.