Porovnanie vplyvu troch metód na výpočet LDL cholesterolu na kategorizáciu rizika kardiovaskulárnych ochorení v troch odlišných populáciách pacientov
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Súbory
Dátum
2024
Názov časopisu
ISSN časopisu
Názov zväzku
Vydavateľ
Slovenská kardiologická spoločnosť : Bratislava
ISBN
ISSN
1338-3655
1338-3760
1338-3760
Abstrakt
Background: Limitations of the Friedewald equation for low-density lipoprotein cholesterol (F-LDLC) calculation, which is used by ≈ 33% of laboratories in Slovakia and 66% of laboratories in Europe, led to the Martin-Hopkins (M-LDLC), extended Martin-Hopkins (extM-LDLC) and Sampson/National Institutes of Health (S-LDLC) equations. We studied these newer calculations of LDLC for correlation and discordance for stratification into the 2019 ESC/EAS Guidelines’ cardiovascular disease (CVD) risk categories.
Methods: We performed analyses on lipid profiles from 3 populations: 873 healthy children from the cross-sectional Slovak Lipid Community Study (population SLCS), records of a 1949 patients of a hospital biochemistry laboratory from from a specialized cardio centre (population VÚSCH), and records of 9113 patients of a hospital biochemistry laboratory from a large general hospital (population FN FDR). Patients were categorized as concordant if LDL-C was up to ≈ 3.4% or 8.9% of patients, respectively, to a higher CVD risk category. The difference between F-LDLC and extM-LDLC or S-LDLC is greater with higher TG, and with lower LDLC. Reliance on the Friedewald equation may result in the underestimation and undertreatment of LDL-C in those at increased risk. We recommend, in line with some national/international guidelines, that clinical laboratories switch to counting and reporting results to extM-LDLC. Fig. 4, Tab. 5, Ref. 42,.
Popis
In: Cardiology Letters. Bratislava : Slovenská kardiologická spoločnosť, 2024. ISSN 1338-3655. Vol. 33, no. 1 (2024), pp. 13-26.
Kľúčové slová
cholesterol, kardiovaskulárne ochorenia
Výstup z projektu
Citácia
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CC BY Creative Commons Attribution 4.0. International
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess