Porovnanie vplyvu troch metód na výpočet LDL cholesterolu na kategorizáciu rizika kardiovaskulárnych ochorení v troch odlišných populáciách pacientov
| dc.contributor.author | Gaško, Rudolf | |
| dc.contributor.author | Alberty, Roman | |
| dc.contributor.author | Studenčan, Martin | |
| dc.contributor.author | Albertyová, Dáša | |
| dc.date.accessioned | 2025-06-17T11:50:41Z | |
| dc.date.available | 2025-06-17T11:50:41Z | |
| dc.date.issued | 2024 | |
| dc.description | In: Cardiology Letters. Bratislava : Slovenská kardiologická spoločnosť, 2024. ISSN 1338-3655. Vol. 33, no. 1 (2024), pp. 13-26. | |
| dc.description.abstract | Background: Limitations of the Friedewald equation for low-density lipoprotein cholesterol (F-LDLC) calculation, which is used by ≈ 33% of laboratories in Slovakia and 66% of laboratories in Europe, led to the Martin-Hopkins (M-LDLC), extended Martin-Hopkins (extM-LDLC) and Sampson/National Institutes of Health (S-LDLC) equations. We studied these newer calculations of LDLC for correlation and discordance for stratification into the 2019 ESC/EAS Guidelines’ cardiovascular disease (CVD) risk categories. Methods: We performed analyses on lipid profiles from 3 populations: 873 healthy children from the cross-sectional Slovak Lipid Community Study (population SLCS), records of a 1949 patients of a hospital biochemistry laboratory from from a specialized cardio centre (population VÚSCH), and records of 9113 patients of a hospital biochemistry laboratory from a large general hospital (population FN FDR). Patients were categorized as concordant if LDL-C was up to ≈ 3.4% or 8.9% of patients, respectively, to a higher CVD risk category. The difference between F-LDLC and extM-LDLC or S-LDLC is greater with higher TG, and with lower LDLC. Reliance on the Friedewald equation may result in the underestimation and undertreatment of LDL-C in those at increased risk. We recommend, in line with some national/international guidelines, that clinical laboratories switch to counting and reporting results to extM-LDLC. Fig. 4, Tab. 5, Ref. 42,. | |
| dc.identifier.doi | https://doi.org/10.4149/Cardiol_2024_1_2 | |
| dc.identifier.issn | 1338-3655 | |
| dc.identifier.issn | 1338-3760 | |
| dc.identifier.uri | https://repo.umb.sk/handle/123456789/624 | |
| dc.identifier.uri | https://zenodo.org/records/14709905 | |
| dc.language.iso | sk | |
| dc.publisher | Slovenská kardiologická spoločnosť : Bratislava | |
| dc.rights | CC BY Creative Commons Attribution 4.0. International | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | cholesterol | |
| dc.subject | kardiovaskulárne ochorenia | |
| dc.title | Porovnanie vplyvu troch metód na výpočet LDL cholesterolu na kategorizáciu rizika kardiovaskulárnych ochorení v troch odlišných populáciách pacientov | |
| dc.title.alternative | Comparison of three methods for LDL-cholesterol calculation for cardiovascular disease risk categorisation in three distinct patient populations | |
| dc.type | Article | |
| dc.type | info:eu-repo/semantics/article |
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