Ru-catalyzed activation of free phenols in a one-step Suzuki Miyaura cross-coupling under mechanochemical conditions
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Súbory
Dátum
2024
Názov časopisu
ISSN časopisu
Názov zväzku
Vydavateľ
Royal Society of Chemistry : Cambridge
ISBN
ISSN
2041-6520
2041-6539
2041-6539
Abstrakt
Activation of phenols by a Ru-catalyst allows for the resulting η5-phenoxo complex to selectively react with a variety of nucleophiles under mechanochemical conditions. Conversion of phenolic hydroxy groups without derivatization is important for late-stage modifications of pharmaceuticals and in the context of lignin-material processing. We present a one-step, Ru-catalyzed cross-coupling of phenols with boronic acids, aryl trialkoxysilanes and potassium benzoyltrifluoroborates under mechano-chemical conditions. The protocol accepts a wide scope of starting materials and allows for gram-scale synthesis in excellent yields. The developed approach constitutes a very interesting and waste-limiting alternative to the known methods.
Popis
In: Chemical Science. Cambridge : Royal Society of Chemistry, 2024. ISSN 2041-6520. Vol. 15, no. 36 (2024), pp. 14798-14805.
Kľúčové slová
mechanochémia, mechanochemistry, fenoly, chémia, chemistry, katalyzátory
Výstup z projektu
APVV-21-0362 Perfluóralkylácia - stratégia diverzifikácie komplexných organických molekúl v neskorej fáze syntézy
Citácia
Práva a licenčné podmienky
CC BY Creative Commons Attribution 4.0. International
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess