Ru-catalyzed activation of free phenols in a one-step Suzuki Miyaura cross-coupling under mechanochemical conditions

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dc.contributor.authorMkrtchyan, Satenik
dc.contributor.authorJakubczyk, Michał
dc.contributor.authorSarfaraz, Sehrish
dc.contributor.authorAyub, Khurshid
dc.contributor.authorIaroshenko, Viktor O.
dc.date.accessioned2025-07-04T12:15:14Z
dc.date.available2025-07-04T12:15:14Z
dc.date.issued2024
dc.descriptionIn: Chemical Science. Cambridge : Royal Society of Chemistry, 2024. ISSN 2041-6520. Vol. 15, no. 36 (2024), pp. 14798-14805.
dc.description.abstractActivation of phenols by a Ru-catalyst allows for the resulting η5-phenoxo complex to selectively react with a variety of nucleophiles under mechanochemical conditions. Conversion of phenolic hydroxy groups without derivatization is important for late-stage modifications of pharmaceuticals and in the context of lignin-material processing. We present a one-step, Ru-catalyzed cross-coupling of phenols with boronic acids, aryl trialkoxysilanes and potassium benzoyltrifluoroborates under mechano-chemical conditions. The protocol accepts a wide scope of starting materials and allows for gram-scale synthesis in excellent yields. The developed approach constitutes a very interesting and waste-limiting alternative to the known methods.
dc.description.sponsorshipAPVV-21-0362 Perfluóralkylácia - stratégia diverzifikácie komplexných organických molekúl v neskorej fáze syntézy
dc.identifier.doihttps://doi.org/10.1039/D4SC01704H
dc.identifier.issn2041-6520
dc.identifier.issn2041-6539
dc.identifier.urihttps://repo.umb.sk/handle/123456789/729
dc.language.isoen
dc.publisherRoyal Society of Chemistry : Cambridge
dc.rightsCC BY Creative Commons Attribution 4.0. International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectmechanochémia
dc.subjectmechanochemistry
dc.subjectfenoly
dc.subjectchémia
dc.subjectchemistry
dc.subjectkatalyzátory
dc.titleRu-catalyzed activation of free phenols in a one-step Suzuki Miyaura cross-coupling under mechanochemical conditions
dc.typeArticle
dc.typeinfo:eu-repo/semantics/article

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