One-step Ru-catalyzed conversion of phenolic OH groups to trifluoromethyl under mechanochemical conditions
Načítavam...
Súbory
Dátum
2024
Názov časopisu
ISSN časopisu
Názov zväzku
Vydavateľ
Cell Press : Cambridge
ISBN
ISSN
2666-3864
Abstrakt
Direct and selective transformation of the phenolic hydroxy group in a concise way without prior derivatization is relevant in many industrial processes, particularly late-stage modification of pharmaceuticals and for lignin-material treatment. The introduction of fluorine has a profound impact on the molecular properties of both small molecules and biopolymers. Herein, we report a Ru-catalyzed transformation of phenols into trifluoromethyl-arenes under mechanochemical conditions. The protocol accepts a wide scope of starting materials and allows for gram-scale synthesis in excellent yields. The developed approach may offer an important alternative to known methods in the context of PASE (pot, atom, and step economy) synthesis and, therefore, green chemistry.
Popis
In: Cell reports physical science. Cambridge : Cell Press, 2024. ISSN 2666-3864. Vol. 5, no. 7 (2024), pp. 1-12.
Kľúčové slová
reaktivita, reaktivity, chémia, chemistry, polyméry, polymers
Výstup z projektu
APVV-21-0362 Perfluóralkylácia - stratégia diverzifikácie komplexných organických molekúl v neskorej fáze syntézy
Citácia
Práva a licenčné podmienky
CC BY-NC-ND Creative Commons Attribution-NonCommercial-NoDerivatives 4.0. International
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess