One-step Ru-catalyzed conversion of phenolic OH groups to trifluoromethyl under mechanochemical conditions

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dc.contributor.authorMkrtchyan, Satenik
dc.contributor.authorJakubczyk, Michał
dc.contributor.authorSarfaraz, Sehrish
dc.contributor.authorAyub, Khurshid
dc.contributor.authorPurohit, Vishal
dc.contributor.authorShalimov, Oleksandr O.
dc.contributor.authorIaroshenko, Viktor O.
dc.date.accessioned2025-07-04T10:06:20Z
dc.date.available2025-07-04T10:06:20Z
dc.date.issued2024
dc.descriptionIn: Cell reports physical science. Cambridge : Cell Press, 2024. ISSN 2666-3864. Vol. 5, no. 7 (2024), pp. 1-12.
dc.description.abstractDirect and selective transformation of the phenolic hydroxy group in a concise way without prior derivatization is relevant in many industrial processes, particularly late-stage modification of pharmaceuticals and for lignin-material treatment. The introduction of fluorine has a profound impact on the molecular properties of both small molecules and biopolymers. Herein, we report a Ru-catalyzed transformation of phenols into trifluoromethyl-arenes under mechanochemical conditions. The protocol accepts a wide scope of starting materials and allows for gram-scale synthesis in excellent yields. The developed approach may offer an important alternative to known methods in the context of PASE (pot, atom, and step economy) synthesis and, therefore, green chemistry.
dc.description.sponsorshipAPVV-21-0362 Perfluóralkylácia - stratégia diverzifikácie komplexných organických molekúl v neskorej fáze syntézy
dc.identifier.doihttps://doi.org/10.1016/j.xcrp.2024.102062
dc.identifier.issn2666-3864
dc.identifier.urihttps://repo.umb.sk/handle/123456789/699
dc.language.isoen
dc.publisherCell Press : Cambridge
dc.rightsCC BY-NC-ND Creative Commons Attribution-NonCommercial-NoDerivatives 4.0. International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectreaktivita
dc.subjectreaktivity
dc.subjectchémia
dc.subjectchemistry
dc.subjectpolyméry
dc.subjectpolymers
dc.titleOne-step Ru-catalyzed conversion of phenolic OH groups to trifluoromethyl under mechanochemical conditions
dc.typeArticle
dc.typeinfo:eu-repo/semantics/article

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