Nanocellulose as a reaction media and stoichiometric reagent for FeCl3-mediated reductive functionalization of nitro compounds
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Súbory
Dátum
2024
Názov časopisu
ISSN časopisu
Názov zväzku
Vydavateľ
The American Chemical Society : Washington
ISBN
ISSN
2168-0485
Abstrakt
Among a wide array of synthetic amides, N-aryl/alkyl amides are an important class of structural motifs having significant importance in pharmaceutical and agrochemical industries. In this regard, a rapid, low-cost, and environmentally friendly synthesis of N-aryl/alkyl amides still remains in a high demand. Herein, we report a convenient route for the mechanochemical synthesis of N-aryl/alkyl amides via FeCl3-catalyzed reductive amidation of nitro compounds, as well as acylation of aliphatic/aromatic amines with carboxylic acids using nanocellulose as the reaction media/stoichiometric reducing agent. The protocol was found to be simple, efficient, and environmentally benign to obtain a diverse array of the respective amides with good to excellent yields. Furthermore, the use of nitro compounds, amines, and carboxylic acids as cheap and readily available starting materials, FeCl3 as a nontoxic catalyst, and nanocellulose as the biodegradable reaction media as well as the stoichiometric reducing agent makes this protocol in the category of a green chemical transformation.
Popis
In: ACS Sustainable Chemistry & Engineering. Washington : The American Chemical Society, 2024. ISSN 2168-0485. Vol. 12, no. 1 (2024), pp. 1-9.
Kľúčové slová
mechanochémia, mechanochemistry, nitrozlúčeniny, nitro compounds, katalýza
Výstup z projektu
APVV-21-0362 Perfluóralkylácia - stratégia diverzifikácie komplexných organických molekúl v neskorej fáze syntézy
Citácia
Práva a licenčné podmienky
CC BY Creative Commons Attribution 4.0. International
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess